Background: The quinazoline are an important class of medicinal compounds that possess a number of biological\nactivities like anticancer, anticonvulsant and antioxidant etc.\nResults: We evaluated the previously synthesized quinazoline derivatives 1ââ?¬â??3 for their anticancer activities against\nthree cancer cell lines (HepG2, MCF-7, and HCT-116). Among the tested compounds, quinazolines 1 and 3 were\nfound to be more potent than the standard drug Vinblastine against HepG2 and MCF-7 cell lines. All the tested compounds\nhad less antioxidant activity and did not exhibit any anticonvulsant activity. Also, molecular docking studies\nwere performed to get an insight into the binding modes of the compounds with human cyclin-dependent kinase 2,\nbutyrylcholinesterase enzyme, human gamma-aminobutyric acid receptor. These compounds showed better docking\nproperties with the CDK2 as compared to the other two enzymes.\nConclusions: The overall study showed that thioxoquinazolines are suitable antitumor agents and they should be\nexplored for other biological activities. Modification in the available lot of quinazoline and synthesis of its novel derivatives\nis essential to explore the potential of this class of compounds. The increase in the threat and with the emergence\nof drug resistance, it is important to explore and develop more efficacious drugs.
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